The 11th Southeast Asian Western Pacific Regional Meeting of Pharmacologists

• Plenary Lecture
• SEAWP Special Lecture
• ASCEPT-JPS Special Lecture
• Special Lectures
• Ebashi Setsuro Award Lecture
• Encouragement of Young Investigator Award Lectures
• SEAWP Symposia
• ASCEPT-JPS Joint Symposium
• JSCPT-JPS Joint Symposium
• JPS Symposia

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PLMarch 23 (Wed) 14：50〜15：50　RoomA（501+502）

Aquaporin water channels: From atomic structure to clinical medicine

【Chair】

Masamitsu Iino

Dept. Pharmacol., Grad. Sch. Med., Univ. Tokyo

【Speaker】

Peter Agre

University Professor and Director, Johns Hopkins Malaria Research Institute, Bloomberg School of Public Health, USA

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SWSLMarch 22 (Tue) 14：50〜15：50　RoomA（501+502）

Control of atrial arrhythmias by microRNAs

【Speaker】

Baofeng Yang

Department of Pharmacology (the State-Province Key Laboratories of Biomedicine-Pharmaceutics of China), Harbin Medical University, China

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ASSLMarch 24 (Thu) 13：10〜14：10　RoomA（501+502）

Allosteric and biased signaling of GPCRs: relevance to novel drug discovery

【Speaker】

Arthur Christopoulos

Monash Institute of Pharmaceutical Sciences, Monash University, Australia

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SL1March 22 (Tue) 10：40〜11：40　RoomA（501+502）

Targeting ALK fusions in human cancer

【Speaker】

Hiroyuki Mano

Division of Functional Genomics, Jichi Medical University /
Department of Medical Genomics, Graduate School of Medicine, The University of Tokyo

SL2March 22 (Tue) 13：40〜14：40　RoomA（501+502）

Novel mechanisms and treatments of heart failure

【Speaker】

Issei Komuro

Department of Cardiovascular Medicine, Graduate School of Medicine, Osaka University

SL3March 23 (Wed) 10：40〜11：40　RoomA（501+502）

Molecular mechanism and treatment strategy of type 2 diabetes

【Speaker】

Takashi Kadowaki

Department of Diabetes and Metabolic Diseases, Graduate School of Medicine, The University of Tokyo

SL4March 23 (Wed) 15：50〜16：50　RoomA（501+502）

Prostaglandins and inflammation: a new concept from receptor-KO mouse studies

【Speaker】

Shuh Narumiya

Department of Pharmacology, Graduate School of Medicine, Kyoto University

SL5March 24 (Thu) 10：40〜11：40　RoomA（501+502）

How to improve pharmaceutical research and development productivity:
drug target discovery through product development

【Speaker】

Masaomi Miyamoto

Research and Development Division, Seikagaku Corporation

SL6March 24 (Thu) 14：20〜15：20　RoomA（501+502）

Alzheimer’s disease: from molecular pathology to disease-modification

【Speaker】

Takeshi Iwatsubo

Department of Neuropathology, Graduate School of Medicine, The University of Tokyo

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EALMarch 23 (Wed) 13：40〜14：40　RoomA（501+502）

Glutamate receptors and brain function

【Speaker】

Masayoshi Mishina

Department of Molecular Neurobiology and Pharmacology, Graduate School of Medicine, The University of Tokyo

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AL1March 23 (Wed) 16：50〜18：20　RoomB（503）

Elucidation of molecular mechanism and exploration of novel therapeutics for spinocerebellar ataxia caused by mutant γPKC

【Speaker】

Takahiro Seki

Department of Molecular and Pharmacological Neuroscience, Graduate School of Biomedical Sciences, Hiroshima University

AL2March 23 (Wed) 16：50〜18：20　RoomB（503）

Study on the role of heterotrimetic G protein signaling pathways for the treatment of heart failure

【Speaker】

Motohiro Nishida

Department of Pharmacology and Toxicology, Graduate School of Pharmaceutical Sciences, Kyushu University

AL3March 23 (Wed) 16：50〜18：20　RoomB（503）

Pharmacological study on Alzheimer's drugs targeting for calcium/calmodulindependent protein kinase Ⅱ

【Speaker】

Shigeki Moriguchi

Department of Pharmacology, Graduate School of Pharmaceutical Sciences, Tohoku University

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SW1March 22 (Tue) 16：00〜17：30　RoomB（503） Traditional medicine in modern pharmacology

【Organizer / Chair】

Zhi-Bin Lin

Dept. of Pharmacol., Sch. of Basic Med. Sciences, Peking Univ. Health Sci. Center, China

Regulation of inflammation process by components from traditional

【Speaker】

Hyeong-Kyu Lee

Bio-Therapeutics Research Inst., Korea Research Inst. of Biosci. & Biotechnology

The study of natural medicine for exploring key pathways of neuroregeneration

【Speaker】

Chihiro Tohda

Div. of Biofunctional Evaluation, Research Center for Ethnomedicine, Inst. of Natural Med., Univ. of Toyama

The role of pharmacology in modernization of traditional Chinese medicine in China

【Speaker】

Zhi-Bin Lin

Dept. of Pharmacol., Sch. of Basic Med. Sciences, Peking Univ. Health Sci. Center

SW2March 23 (Wed) 9：00〜10：30　RoomB（503） Pharmacometabolomics

【Organizer / Chair】

Young-Ran Yoon

Kyungpook National Univ., Daegu, Korea

【Chair】

Daniel Tsun-Yee Chiu

Grad. Inst. of Med. Biotechnology, Chang Gung Univ.

Metabolomic studies of G6PD-knockdown cells

【Speaker】

Daniel Tsun-Yee Chiu

Grad. Inst. of Med. Biotechnology, Chang Gung Univ.

Pharmaco-metabonomics: a crystal ball for future?

【Speaker】

Huiru Tang

Wuhan Centre for Magnetic Resonance, Wuhan Inst. of Physics and Mathematics, the Chinese Academy of Sciences

Pharmacometabolomic study of drug responses

【Speaker】

Young-Ran Yoon

Kyungpook National Univ. Sch. of Med., Dept. of Molecular Med. & Clinical Trial Center of Kyungpook National Univ. Hosp.

SW3March 23 (Wed) 10：30〜12：00　RoomB（503） Oxidative stress as a pharmacological target

【Organizer/Chair】

Samuel H.H. Chan

Center for Translational Research in Biomed. Sciences, Chang Gung Memorial Hosp.-Kaohsiung Med. Center, Taiwan

Oxidative stress-mediated central circulatory regulatory failure underlies methamphetamine-induced fatal cardiovascular collapse

【Speaker】

Alice Y.W. Chang

Center for Translational Research in Biomed. Sciences, Chang Gung Memorial Hosp.-Kaohsiung Med. Center, China

Pivotal role of oxidative stress within the cardiovascular center in hypertension: angiotensin II and apoptotic signaling pathway

【Speaker】

Yoshitaka Hirooka

Dept. of Cardiovascular Med., Kyushu Univ. Grad. Sch. of Med. Sciences

Antioxidants as novel therapeutic targets against neurogenic hypertension

【Speaker】

Julie Y.H. Chan

Dept. of Med. Education and Research, Kaohsiung Veterans General Hosp.

SW4March 23 (Wed) 13：10〜14：40　RoomB（503） In vitro - in vivo extrapolation: realising the promise

【Organizer/Chair】

John Miners

Dept. of Clinical Pharmacol. Flinders Univ. Sch. of Med. Flinders Med. Centre, Australia

Reaction phenotyping and quantitative in vitro - in vivo extrapolation:
application to drugs cleared by glucuronidation

【Speaker】

John O. Miners

Dept. of Clinical Pharmacol., Flinders Univ. Sch. of Med., Flinders Med. Centre

Quantitative prediction of hepatic clearance for anionic drugs based on in vitro experiments

【Speaker】

Hiroyuki Kusuhara

Grad. Sch. of Pharmaceutical Sciences, The Univ. of Tokyo

Issues in predicting inter-individual variability of pharmacokinetics

【Speaker】

Akihiro Hisaka

The University of Tokyo Hospital

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ASJPMarch 24 (Thu) 10：30〜12：00　RoomB（503） Ion channels in disease and as pharmacological targets

【Organizer】

Gregory Monteith

The Univ. of Queensland

【Chair】

Yasuo Mori

Kyoto Univ.

ORAI calcium channels and their regulators in breast cancer

【Speaker】

Gregory Raymond Monteith

The Univ. of Queensland
 

TRP channel modulation by small molecules

【Speaker】

Yasuo Mori

Dept. of Synthetic Chemistry and Biological Chemistry, Grad. Sch. of Engineering, Kyoto Univ.

Accelerated biodiscovery of ion channel modulators

【Speaker】

Irina Vetter

Inst. for Molecular Biosci., The Univ. of Queensland

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JSMarch 24 (Thu) 14：20〜15：50　RoomB（503） New pharmacological approach to alleviation of adverse drug reactions

【Organizers】

Shinichiro Ueda

Ryukyu Univ.

Ryozo Oishi

Kyushu Univ.

Circadian clock gene regulation and cardiovascular therapy

【Speaker】

Koichi Node

Dept. of Cardiovascular & Renal Med., Saga Univ.

Implications for drug safety from a drug timing

【Speaker】

Shigehiro Ohdo

Dept. Pharmaceutics, Grad. Sch. Pharm. Sci., Kyushu Univ.

Alleviation of adverse drug reactions by EcoPharma

【Speaker】

Ryozo Oishi

Dept. Pharmacy, Kyushu Univ. Hosp.

Pharmacogenomic approaches for anticipating and avoiding adverse drug reactions

【Speaker】

Hirotoshi Echizen

Dept. Pharmacotherapy

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S1A1March 22 (Tue) 9：00〜10：30　RoomA（501+502） Research and development strategy of agents for cancer therapy

【Organizers】

Yasuhiro Funahashi

Eisai Co., Ltd.

Shiro Soga

Kyowa Hakko Kirin

Preclinical discovery research of E7820, a novel angiogenesis inhibitor inducing tumor vascular normalization

【Speaker】

Taro Semba

Oncology PCU, Eisai Co.,

Drug discovery and research of heat shock protein 90 (Hsp90) inhibitor

【Speaker】

Shiro Soga

Drug Discovery Research Lab., Kyowa Hakko Kirin

Progress in research and development of MAPK pathway inhibitors

【Speaker】

Yuko Aoki

Research Div. Chugai Co. LTD

R&D approach targeting RTK by c-Met and HER3 signal inhibitors

【Speaker】

Kouichi Akahane

Oncol. Res. Lab., Daiichi Sankyo

S1B2March 22 (Tue) 9：00〜10：30　RoomB（503） Research and development strategy of agents for cancer therapy

【Organizers】

Haruaki Nakaya

Chiba Univ.

Tetsushi Furukawa

Tokyo Med. and Dental Univ.

The metabolic syndrome and homeostatic inflammation

【Speaker】

Yoshihiro Ogawa

Dept. Mol. Med. & Metab., Med. Res. Inst., Tokyo Med. Dent. Univ.

Role of chronic inflammation in the pathogenesis of atherosclerosis

【Speaker】

Masataka Sata

Dept. Cardiovascular Med., Univ. Tokushima. Sch. Med.

Cardiac inflammation and heart failure

【Speaker】

Tohru Minamino

Dept. of Cardiovasc. Sci. Med., Chiba Univ. Sch. Med.

ATP plays a role as a "Danger signal" in atrial fibrillation

【Speaker】

Tetsushi Furukawa

Dept. Bio-Inform. Pharmacol., MRI, Tokyo Med. Dent. Univ.

S1C3March 22 (Tue) 9：00〜10：30　RoomC（411+412） New findings about multiple roles of adenosine A1 receptors in the regulation of CNS functions

【Organizers】

Yuko Sekino

National Inst. of Health Sciences

Tomoaki Shirao

Gunma Univ.

The basic mechanism of a ketogenic diet: an autocrine regulation via adenosine A1 receptors

【Speaker】

Masahito Kawamura

Dept. Pharmacol., Jikei Univ. Sch. Med.
Neurosci. Program/Psychology Dept., Trinity Col.

Involvement of adenosine A1 receptors in regulation of axonal conduction of action potentials

【Speaker】

Yoshihiko Yamazaki

Dept. Physiol., Yamagata Univ. Sch. Med.

Regulation of NMDA receptor functions by Adenosine A1 receptors

【Speaker】

Hideki Miwa

Dept. Genet and Behav Neurosci., Gunma Univ. Grad. Sch. Med. / JST CREST

Adenosine A1 receptor regulates metabotropic glutamate receptor signaling and synaptic plasticity in central neurons

【Speaker】

Toshihide Tabata

Lab. Neural Info. Tech., Grad. Sch. Scis. & Eng., Univ. Toyama

S1I4March 22 (Tue) 9：00〜10：30　RoomI（315） Recent advances in the research on Rho family GTPase signaling and its application to pharmacology

【Organizers】

Kozo Kaibuchi

Nagoya Univ.

Takehiko Ueyama

Kobe Univ.

A proteomic approach for comprehensively screening substrates of protein kinases

【Speaker】

Mutsuki Amano

Dept. Cell Pharmacol., Nagoya Univ. Sch. Med.

Rho signaling in developing nervous system

【Speaker】

Dean Thumkeo

Dept. Pharmacol., Kyoto Univ. Sch. Med.

Regulatory mechanisms of Rac activation by RhoGDI

【Speaker】

Takehiko Ueyama

Lab. of Mol. Pharmacol., Biosignal Research Center, Kobe Univ.
Dept. of Physiol., Nagoya Univ. Grad. Sch. of Med.

An activity map of Rho-family GTPases during cystogenesis

【Speaker】

Etsuko Kiyokawa

Dept. Pathol. Biol. Diseases, Kyoto Univ. Sch. Med.

S1B5March 22 (Tue) 10：30〜12：00　RoomB（503） A new turn of basic research for stem cells and medical science of epigenetics

【Organizers】

Minoru Narita

Hoshi Univ.

Hirotaka J. Okano

Keio Univ.

Epigenetic signatures of adipose tissue-derived mesenchymal stem cells

【Speaker】

Takahiro Ochiya

Div. Mol. Cell Med., Natl Cancer Ctr RI

Stem cells in the adult brain

【Speaker】

Kazunobu Sawamoto

Dept. Dev. Regen. Biol., Nagoya City Univ. Grad. Sch. Med. Sci.

Is epigenetic modification critical for refractory diseases?

【Speaker】

Minoru Narita

Dept. Toxicol., Hoshi Univ. Sch. Pharm. Pharmaceut. Sci.

Neurodegenerative disease-specific induced pluripotent stem cell research

【Speaker】

Haruhisa Inoue

CiRA, Kyoto Univ.
JST, CREST

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S1C6March 22 (Tue) 10：30〜12：00　RoomC（411+412） Molecular dynamics of G protein-coupled receptors revealed by imaging techniques

【Organizers】

Hitoshi Kurose

Kyushu Univ.

Akira Hirasawa

Kyoto Univ.

Application of fluorescent imaging technology to GPCR ligand screening

【Speaker】

Akira Hirasawa

Dept. Genomic Drug Discovery Sci., Grad. Sch. Pharmaceu. Sci. Kyoto Univ.

Ligand-induced structural rearrangements of G protein coupled receptors revealed by FRET analysis

【Speaker】

Michihiro Tateyama

Div. Biophysics & Neurobiol., Dept. Mol. Physiol., NIPS

Monomer-dimer dynamic equilibrium of GPCR: direct observation by single molecule imaging

【Speaker】

Rinshi S. Kasai

Inst. Front. Med. Sci., Kyoto Univ.
iCeMS, Kyoto Univ.

Induction of cardiac fibrosis by β-blocker in G protein-independent but GRK5/β -arrestin2-dependent signaling pathways

【Speaker】

Michio Nakaya

Dept. Pharmacol. Toxicol., Kyushu Univ. Sch. Pharm. Sci.

S1I7March 22 (Tue) 10：30〜12：00　RoomI（315） Protein kinase C-subtypes as molecular targets for the therapy of incurable diseases

【Organizers】

Hiroyuki Fukui

Univ. Tokushima

Naoaki Saito

Kobe Univ.

Novel binding of PKCη to RalA and its crucial role in morphological change during keratinocytes differentiation

【Speaker】

Yasuhito Shirai

Biosci., Grad. Sch. of Agricultural Sci., Kobe Univ.

PKCδ as a target molecule of natural resources-derived anti-allergic compounds that suppress up-regulation of allergic diseases sensitive gene expression

【Speaker】

Hiroyuki Mizuguchi

Dept. Mol. Pharmacol., Inst. of Health-Biosciences, The Univ. Tokushima Grad. Sch.

Possible involvement of protein kinase C-dependent changes in the neuronal activities at the spinal cord on the refractory mechanism of neuropathic pain

【Speaker】

Satoshi Imai

Dept. Toxicol., Hoshi Univ. Sch. Pharm. Pharmaceut. Sci.

Etiology of neuronal diseases induced by the mutation in PKCγ gene

【Speaker】

Naoaki Saito

Lab. Mol. Pharm., Biosignal Res. Ctr., Kobe Univ.

S1B8March 22 (Tue) 13：10〜14：40　RoomB（503） Translational research for the development of Quality of Life of cancer patients
- contribution by the pharmacological research approach

【Organizers】

Mechanism and management of chemotherapeutic agents-induced peripheral neuropathy

【Speaker】

Takehiro Kawashiri

Grad. Sch. Pharm. Sci., Kyushu Univ.

NK1 receptor antagonist aprepitant: active antiemetic for the prevention of chemotherapy-induced delayed nausea and vomiting

【Speaker】

Masaaki Kawahara

Dept. Med. Oncology, KKR Otemae Hosp.

Role of TRPV1-positive primary afferent neurons in bone cancer pain

【Speaker】

Tomoyuki Kawamata

Dept. Anesth & Resus., Shinshu Univ. Sch. Med.

A study that aimed at the treatment of the cancer cachexia with the pharmacological approach

【Speaker】

Kiyoshi Terawaki

Cancer Pathophysiol. Div., NCCRI

S1C9March 22 (Tue) 13：10〜14：40　RoomC（411+412） Molecular basis of exocytosis

【Organizers】

Mitsunori Fukuda

Lab. Membrane Trafficking Mechanisms, Grad. Sch. Life Sci., Tohoku Univ.

Role of Rab small GTPases in secretory cells

【Speaker】

Thomas F.J. Martin

Dept. of Biochemistry, Univ. of Wisconsin

Priming calcium-regulated vesicle exocytosis

【Speaker】

Thomas F.J. Martin

Dept. of Biochemistry, Univ. of Wisconsin

Modulation of regulated exocytosis by PRIP, a protein phosphatase interacting molecule

【Speaker】

Hiroshi Takeuchi

Lab. Mol. Cell. Biochem., Fac. Dent. Kyushu Univ.

Molecular mechanisms of insulin granule exocytosis

【Speaker】

Tadao Shibasaki

Div. Cell. Mol. Med. Kobe Univ. Grad. Sch. Med.

S1H10March 22 (Tue) 13：10〜14：40　RoomH（313+314） New transgenic mouse models for drug development

【Organizers】

Hirofumi Kai

Kumamoto Univ.

Tetsuya Taga

Tokyo Med. and Dental Univ.

A novel mouse model of obstructive pulmonary disease with mucus accumulation

【Speaker】

Tsuyoshi Shuto

Dept. Mol. Med., Grad. Sch. Pharm. Sci., Kumamoto Univ.
G-COE "Cell Fate Reg. Res. Edu. Unit., Kumamoto Univ.

Novel type of "knock-in" mouse model for Alzheimer's disease

【Speaker】

Takashi Saito

RIKEN Brain Sci. Inst.

Genetic manipulation of nephron progenitors

【Speaker】

Ryuichi Nishinakamura

Inst. Mol. Emb. Genet., Kumamoto Univ.

Establishment of a new mouse model of neurodevelopmental disorder

【Speaker】

Tetsuya Taga

Dept. Stem Cell Regul., Med. Res. Inst., Tokyo Med. & Dent. Univ.

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S1I11March 22 (Tue) 13：10〜14：40　RoomI（315） The new approach for research of improvement of higher brain function

【Organizers】

Kumiko Ishige

Nihon Univ.

Naoko Kuzumaki

Hoshi Univ.

Neurogenesis and oligogenesis: their implication and mechanisms

【Speaker】

Noriko Osumi

Tohoku Univ. Grad. Sch. of Med.

The role of neural stem cells in neurological and psychiatric diseases

【Speaker】

Naoko Kaneko

Dept. Developmental and Regenerative Biol., Nagoya City Univ. Grad. Sch. of Med. Sciences

Molecular mechanism of neural stem cell differentiation associated with aging

【Speaker】

Naoko Kuzumaki

Dept. Toxicol., Hoshi Univ. Sch. Pharm. Pharmaceut. Sci.

Circadian modulation of cognitive performance in BMAL1KO and AD model mice

【Speaker】

Kumiko Ishige

Research unit of Pharmacol., Sch. of Pharm., Nihon Univ.

S1A12March 22 (Tue) 16：00〜17：30　RoomA（501+502） Research and development strategy of agents for cardiovascular diseases

【Organizers】

Toshiro Shibano

Daiichi Sankyo Co., Ltd.

Akira Saito

Mitsubishi Tanabe Pharma Corporation

Development of a novel antihypertensive agent:
a potent and long-lasting angiotensin type1 receptor blocker, TAK-536

【Speaker】

Keiji Kusumoto

Pharmacol. Res. Lab, Takeda Pharmaceutical Company Ltd.

Pharmacologic strategy for the treatment of resistant hypertension

【Speaker】

Kohei Kikkawa

Pharmacol. Res. Lab. II, Mitsubishi Tanabe Pharma Corp.

Combination therapy for antihypertensive patients:
focused on end-organ protection

【Speaker】

Makoto Mizuno

Biological Research Laboratories, Daiichi Sankyo Co., Ltd.

Development of drug for pulmonary arterial hypertension :
a novel therapeutic approach to diseases with enhanced protein phosphorylation

【Speaker】

Minoru Seto

Lab. Pharmacol., AsahiKASEI Pharma

S1C13March 22 (Tue) 16：00〜17：30　RoomC（411+412） Current status and future scope of translational research on acute lung injury

【Organizers】

Yuichi Hattori

Univ. of Toyama

Naoyuki Matsuda

Nagoya Univ.

Clinical features of acute lung injury and acute respiratory distress syndrome

【Speaker】

Satoru Hashimoto

ICU, Kyoto Pref. Univ. Med.

Pathogenesis and therapeutic targets for virus-mediated respiratory failure

【Speaker】

Yumiko Imai

Dept. Biological Informatics and Experimental Therapeutics, Akita Univ. Sch. Med

Protection from pulmonary apoptosis: a new therapeutic choice for septic acute lung injury

【Speaker】

Ken-ichi Takano

Dept. of Mol. & Med. Pharmacol., Grad. Sch. of Med. & Pharm. Sci., Univ. of Toyama

Alert cell strategy for inflammation and cell death in septic ALI/ARDS

【Speaker】

Naoyuki Matsuda

Dept. Emergency&CCM., Nagoya Univ. Sch. Med.

S1H14March 22 (Tue) 16：00〜17：30　RoomH（313+314） New therapeutic strategy for amino acid medicine

【Organizers】

Koji Takeuchi

Kyoto Pharmaceutical Univ.

Hisayuki Uneyama

Ajinomoto Co., Inc.

Mechanisms of glycine on sleep

【Speaker】

Makoto Bannai

Inst. for Innovation, Ajinomoto Co., Inc.

Notable functions of branched chain amino acids as a biological regulator

【Speaker】

Fumiaki Yoshizawa

Dept. Bioproductive Sci., Utsunomiya Univ.

Effects of dietary glutamate to gut and brain function

【Speaker】

Akihiko Kitamura

Nutr. Physiol., Inst. for Innovation, Ajinomoto Co., Inc.

Glutamate protects the small intestine against NSAID-induced damage in rats

【Speaker】

Kikuko Amagase

Dept. Pharmacol. Exp. Ther., Kyoto Pharm. Univ.

S1I15March 22 (Tue) 16：00〜17：30　RoomI（315） Mechanisms underlying initiation and modulation of purinergic system

【Organizers】

Schuichi Koizumi

Univ. of Yamanashi

Structure and function of vesicular nucleotide transporter (VNUT)

【Speaker】

Yoshinori Moriyama

Dept. Membrane Biochem. Okayama Univ. Grad. Sch. Med. Den. Pharmaceutical Sci.

ATP-mediated information transmission downstream of TRP channel activation

【Speaker】

Makoto Tominaga

Div. Cell Signaling, Okazaki Inst. Integrative Biosci.
Dept. Physiol. Sci., SOKENDAI

Astrocytic ATP release and brain function

【Speaker】

Schuichi Koizumi

Dept. Neuropharmacol., Interdisciplinary Grad. Sch. Med. and Engineering, Univ. Yamanashi

The role of adenosine in sleep-wake regulation

【Speaker】

Yoshihiro Urade

Dept. Mol. Behav. Biol., Osaka Biosci. Inst.

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S2A16March 23 (Wed) 9：00〜10：30　RoomA（501+502） Research and development strategy of agents for schizophrenia

【Organizers】

Takahiko Yano

Takeda Pharmaceutical Co., Ltd.

Shigeyuki Chaki

Taisho Pharmaceutical Co.,Ltd.

Trends in the development of new animal models toward novel drug discovery for schizophrenia

【Speaker】

Kazuhito Ikeda

Pharmacol. Research Laboratories, Dainippon Sumitomo Pharma Co., Ltd.

Imaging biomarkers in schizophrenia

【Speaker】

Satoshi Ozaki

Bioimaging Research Labs., Astellas Pharma Inc.

Next wave-1:
group II metabotropic glutamate receptor agonists as a potential drug for schizophrenia

【Speaker】

Shigeyuki Chaki

Discov. Pharmacol., Mol. Func. Pharmacol. Labs., Taisho Pharmaceutical Co., Ltd.

Next wave-2:
approach for finding novel targets from risk factors of schizophrenia

【Speaker】

Takahiko Yano

Pharmacol. research laboratories, PRD, Takeda Pharmaceutical Company

S2C17March 23 (Wed) 9：00〜10：30　RoomC（411+412） The research frontline of drug transport as the basis for drug discovery and therapeutic development

【Organizers】

Naohiko Anzai

Kyorin Univ.

Hiroyuki Kusuhara

The Univ. of Tokyo

Identification of a novel human renal organic anion efflux related to pharmacological effect and adverse reaction

【Speaker】

Promsuk Jutabha

Dept. Pharmacol. Toxicol., Kyorin Univ. Sch. Med.

Use of the data from genome-wide association study (GWAS) for pharmacogenomics and new drug development: focusing on transporter genes

【Speaker】

Naoyuki Kamatani

Center Genom. Med., RIKEN

Pharmacogenomics of drug transporters and transporter-mediated drug- and fooddrug interactions

【Speaker】

Ichiro Ieiri

Dept. Clin. Pharmacokinet., Grad. Sch. Kyushu Univ.

Confounding factors in drug disposition : pharmacogenetics of drug transporters

【Speaker】

Im Sook Song

Dept. of Pharmacol. and Pharmacogenomics Research Center, Inje Univ. College of Med.

S2I18March 23 (Wed) 9：00〜10：30　RoomI（315） Functional control of the brain and autonomic nervous system by new regulatory factors and their drug development

【Organizers】

Nobuyuki Yanagihara

Univ. Occup. & Env. Health

Kiyofumi Yamada

Nagoya Univ.

Possible control of life span by hibernation hormone, HP complex, activated in the brain

【Speaker】

Noriaki Kondo

Tamagawa Univ. Res. Inst.

The roles of vasopressin in the olfactory bulb in anticipation of the drug development

【Speaker】

Hirofumi Hashimoto

Centre for Integrative Physiology, College of Med. and Veterinary Med., Univ. of Edinburgh

Receptor for advanced glycation endproducts: a potential target for amyloid-β peptide-mediated neuropathology

【Speaker】

Kazuhiro Takuma

Lab. Medicinal Pharmacol., Grad. Sch. Pharmaceut. Sci., Osaka Univ.

New insights into pharmacological potential of plant flavonoids on catecholamine signaling

【Speaker】

Nobuyuki Yanagihara

Dept. Pharmacol., Univ. Occup. & Env. Health, Sch. Med.

S2C19March 23 (Wed) 10：30〜12：00　RoomC（411+412） Dysfunction of transportsome in diseases and its possibility as therapeutic targets:
the next generation of transporter research

【Organizers】

Satomi Kita

Fukuoka Univ.

Takayuki Nakagawa

Kyoto Univ.

Overview: transportsome as a fundamental unit for the onset of diseases

【Speaker】

Naohiko Anzai

Dept. Pharmacol., Kyorin Univ. Sch. Med.

Transportsome in biliary cholesterol secretion

【Speaker】

Tappei Takada

Dept. of Pharm., Univ. of Tokyo Hosp.

Functional interaction between Na+/Ca2+ exchanger and sodium-transporting proteins in plasmamembrane microdomain

【Speaker】

Satomi Kita

Dept. Pharmacol., Facul. Med., Fukuoka Univ.

Transportsome in renal tubules

【Speaker】

Yumi Noda

Dept. Nephrol. Chronic Kidney Dis.

S2H20March 23 (Wed) 10：30〜12：00　RoomH（313+314） Pathophysiological function and drug discovery of 5-hydroxytryptamine in gastrointestinal diseases

【Organizers】

Masatoshi Hori

The Univ. of Tokyo

Shinichi Kato

Kyoto Pharmaceutical Univ.

Immunohistochemical analysis of altered serotonin signaling and transient　receptor potential vanilloid (TRPV) 1 channels in experimental colitis mice

【Speaker】

Kenjiro Matsumoto

Dept. Pharmacol., Josai Int. Univ.

Role of serotonin 5-HT3 receptor in the pathogenesis of IBS with diarrhea

【Speaker】

Takuya Hirata

Appl Pharmacol. Res Labs, Astellas Pharma Inc.

Role of serotonin in regulation of inflammatory responses in the gut

【Speaker】

Shinichi Kato

Div. Pathol. Sci., Dept. Pharmacol. Exp. The., Kyoto Pharm. Univ.

Stimulation with 5-HT4 receptor induces anti-inflammatory actions via α7nACh　receptors on muscularis macrophages associated with postoperative ileus

【Speaker】

Masatoshi Hori

Dept. of Vet. Pharmacol., Grad. Sch. of Agri. and Life Sci., The Univ. of Tokyo

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S2I21March 23 (Wed) 10：30〜12：00　RoomI（315） Application of imaging techniques for drug discovery of next generation

【Organizers】

Toshio Tanaka

Mie Univ.

Masatoshi Hagiwara

Kyoto Univ.

Application of novel in vivo imaging and omics technology in drug discovery

【Speaker】

Yuhei Nishimura

Dept. Mol. and Cell. Pharmacol., Pharmacogenomics and Pharmacoinformatics, Mie Univ. Grad. Sch. Med.
Mie Univ. Med. Zf Res. Cent.
Dept. of Med. Chemogenomics, Mie Univ. VBL
Dept. Bioinfo., Mie Univ. Life Sci. Res. Cent.

Drug discovery and development using omics and molecular imaging technologies

【Speaker】

Ryuji Hiramatsu

Genomic Sci. Lab., Dainippon Sumitomo Pharma. Co.,Ltd.

Innovative drug development by multi-phase application of molecular imaging

【Speaker】

Yasuyoshi Watanabe

RIKEN Center for Mol. Imag. Sci.
Dept. Physiol., Osaka City Univ. Grad. Sch. Med.

mRNA splicing imaging and new therapeutics for RNA diseases

【Speaker】

Masatoshi Hagiwara

Dept. Anat. & Deve. Biol., Kyoto Univ. Sch. Med.

S2C22March 23 (Wed) 13：10〜14：40　RoomC（411+412） Environmental insults for psychiatric disorders on multiple life stages and the implications for pharmaceutical development

【Organizers】

Tomoyuki Furuyashiki

Kyoto Univ.

Taku Yamaguchi

Hokkaido Univ.

Social deficits induced by early postnatal stress

【Speaker】

Taku Yamaguchi

Dept. Neuropharmacol., Hokkaido Univ. Grad. Sch. Med.

Npas4 is a stress-responsible transcription factor that regulates neuronal function: implication in neuropsychiatric disorders

【Speaker】

Taku Nagai

Dept. Neuropsychopharmacol. Hosp. Pharm., Nagoya Univ. Grad. Sch. Med.
CREST, JST

Roles of prostaglandin E2 in emotional behavior under acute and chronic stress

【Speaker】

Tomoyuki Furuyashiki

Dept. Pharmacol., Kyoto Univ. Grad. Sch. Med.

Pharmacological treatment strategies targeting cognitive impairment associated with aging

【Speaker】

Ming Teng Koh

Dept. of Psychological and Brain Sciences, Johns Hopkins Univ.

S2H23March 23 (Wed) 13：10〜14：40　RoomH（313+314） Hydrogen sulfide as a signal molecule as well as a cytoprotectant

【Organizers】

Hideo Kimura

NCNP

Ichiro Niki

Oita Univ.

Hydrogen sulfide: its production, release and function

【Speaker】

Hideo Kimura

Dept. Mol. Phrmacol., Natl. Inst. Neurosci. NCNP.

Hydrogen sulphide stimulates gastroduodenal HCO3 - secretion

【Speaker】

Shusaku Hayashi

Dept. Pharmacol. Exp. Ther., Kyoto. Pharm. Univ.
Div. Gastrointest. Pathophysiol., Inst. Natural Med., Univ. Toyama

Hydrogen sulfide production (H2S) and its protective roles in pancreatic beta cells

【Speaker】

Ichiro Niki

Dept. Pharmacol.,Oita Univ. Faculty Med.,

The role of hydrogen sulfide in diabetic nephropathy (DN)

【Speaker】

Yukio Yuzawa

Dept. of Nephrology, Fujita Health Univ. Sch. of Med.

S2I24March 23 (Wed) 13：10〜14：40　RoomI（315） An extremely small size mini-pig made in Japan (MicrominipigTM): evolution as a medical research tool

【Organizers】

Atsushi Sugiyama

T

oho Univ.

Yasukatsu Izumi

Osaka City Univ.

Pigs as the preclinical model for medical research

【Speaker】

Eiji Kobayashi

CDAMTec. Jichi Med. Univ.

Microminipigs: drug oxidation activities in liver microsomes comparable with humans

【Speaker】

Hiroshi Yamazaki

Showa Pharma Univ.

Microminipig: potential utility as a tool in safety pharmacology

【Speaker】

Yasuki Akie

Dept. Pharmacol., Sch. Med., Fac. Med., Toho Univ.
SUGI Inst. of Biological Sci. Co., Ltd

Microminipig: research models to break through cardiovascular disease

【Speaker】

Hiroaki Kawaguchi

Dept. Vet. Exp. Ani. Sci., Agri., Kagoshima Univ.

S2A25March 23 (Wed) 16：50〜18：20　RoomA（501+502） Research and development of agents for pain

【Organizers】

Toshiaki Aoki

Astellas Pharma Inc.

Syuzo Watanabe

RaQualia Pharma Inc.

Immunoregulatory molecules reveal crosstalk between immune and pain responses

【Speaker】

Kenzo Muramoto

Tsukuba Research Laboratories, Eisai Co., Ltd.

Development of an animal model of fibromyalgia-like chronic pain and its use in drug discovery research

【Speaker】

Yukinori Nagakura

Dept. Pain Res., Pharmacol. Res. Labs., Astellas Pharma Inc.

Voltage-gated sodium channel blocker for the treatment of neuropathic pain

【Speaker】

Shuzo Watanabe

RaQualia Pharma Inc.

TRP channel ligands as novel analgesics for neuropathic pain

【Speaker】

Tatsuya Kamei

Pharmacol. Research Lab., Dainippon Sumitomo Pharma Co., Ltd.

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S2C26March 23 (Wed) 16：50〜18：20　RoomC（411+412） The present and future of molecular imaging, and its potential for drug discovery and development

【Organizers】

Kazuhiko Yanai

Tohoku Univ.

Hideaki Hara

Gifu Pharmaceutical Univ.

Development of pet probes for imaging biomarker

【Speaker】

Shozo Furumoto

Dept. Pharmacol., Tohoku Univ. Sch. Med.

Development of pre-clinical PET system

【Speaker】

Katsumi Sekikawa

Shimadzu corporation

Brain imaging in laser-induced ocular hypertensive monkeys using PET and MRI

【Speaker】

Masamitsu Shimazawa

Mol. Pharmacol. Dept. Biofunct. Eval., Gifu Pharmaceut. Univ.

Role of bioimaging technology to drug discovery research

【Speaker】

Shintaro Nishimura

Bioimaging Res. Labs., Astellas Pharma Inc.

S2H27March 23 (Wed) 16：50〜18：20　RoomH（313+314） Approach of alternative to animal experiments in Asia

【Organizer】

Yuji Yoshiyama

Kitasato Univ.

Alternatives to animal experiments in pharmacology

【Speaker】

Yasuo Ohno

Nat. Inst. Health Sci.

Current status of alternative testing in Japan

【Speaker】

Hajime Kojima

JaCVAM, NIHS

Asian research trends in alternatives to animal experimentation

【Speaker】

Tsutomu Kurosawa

Dept. of Laboratory Animal Med., Osaka Univ. Med. Sch.

Development of short-term in vitro testing systems for hazardous chemicals by NEDO

【Speaker】

Noriho Tanaka

Div. Alternative Res. Hatano Res. Inst., Food & Drug Safety Ctr.

S2I28March 23 (Wed) 16：50〜18：20　RoomI（315） Opening the era for drug design research driven by new microscopic technology

【Organizers】

Mutsuo Nuriya

Keio Univ.

Yuji Ikegaya

The Univ. of Tokyo

Nipkow-disk confocal microscopy towards neuronal networks at work

【Speaker】

Takuya Sasaki

Lab. Chem. Pharmacol., Grad. Sch. Pharm., Tokyo Univ.
Saitama Univ., BSI

Neural functions revealed by new methods of chemical biology and optogenetics

【Speaker】

Masanori Matsuzaki

Div. Brain Circuits, National Inst. for Basic Biology
SOKENDAI

Membrane potential dynamics in neurons probed by the second harmonic generation imaging

【Speaker】

Mutsuo Nuriya

Dept. Pharmacol., Keio Univ. Sch. Med.

Imaging mass spectrometry (IMS): a novel imaging tool to visualize the spatial distribution of drug in whole-body sections

【Speaker】

Mitsutoshi Setou

Dept. Mol. Anat. Hamamatsu Univ. Sch. Med.

S3A29March 24 (Thu) 9：00〜10：30　RoomA（501+502） Translational research

【Organizers】

Hisaharu Yamada

Taisho Pharmaceutical Co.,Ltd.

Segyoku Ryu

Takeda Pharmaceutical Co., Ltd.

Biomarker development in drug discovery and development

【Speaker】

Akira Shinagawa

Clin. Pharm & Transl. Med. Dept., R&D Div., Daiichi-Sankyo Co.,Ltd.

Application of microdose clinical studies to drug discovery and development:
to improve the probability of success of development process

【Speaker】

Yoshiyuki Yamaura

Discovery Technology Lab., ONO Pharmaceutical. Co., Ltd

Moving pharmacogenomics into clinical practices

【Speaker】

Shyh-Yuh Liou

Clinical Data Sci. Dept, Japan Develop. Center, Pharm. Develop. Div. Takeda Pharm. Co. Ltd.

Application of bioimaging technology to translational research

【Speaker】

Shintaro Nishimura

Bioimaging Res. Labs., Astellas Pharma Inc.

S3B30March 24 (Thu) 9：00〜10：30　RoomB（503） New approaches to ion channels as a target for drug discovery and novel screening methods

【Organizers】

Yuji Imaizumi

Nagoya City Univ.

Syuji Kaneko

Kyoto Univ.

Overview of ion channels as a target for drug discovery and novel screening methods

【Speaker】

Yuji Imaizumi

Dept. Mol. & Cell. Pharmacol., Grad. Sch. Pharmaceut. Sci., Nagoya City Univ.

Voltage-sensing phosphatase: mechanisms and applications

【Speaker】

Yasushi Okamura

Grad. Sch. of Med., Osaka Univ.

Automated planar patch clamp-accelerating ion channel drug discovery

【Speaker】

Martin Gosling

Respiratory Disease Area, Novartis Inst. of Biomed. Research

An automated electrophysiological system for the measurement of transporter/ channel activities

【Speaker】

Shuji Kaneko

Dept. Mol. Pharmacol., Kyoto Univ. Grad. Sch. Pharm. Sci.

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S3C31March 24 (Thu) 9：00〜10：30　RoomC（411+412） Drugs for the treatment of metabolic bone disease: the development of drug therapy based on the new molecular mechanisms

【Organizers】

Keiichi Otani

Tokyo Med. and Dental Univ.

Akifumi Togari

Aichi Gakuin Univ.

Osteonetwork and its application to drug discovery

【Speaker】

Shu Takeda

Dept. Internal Med., Keio Univ. Sch. Med.

New drug targets from the viewpoint of osteoimmunology

【Speaker】

Tomoki Nakashima

Dept. Cell Signal., TMDU
JST, ERATO, Takayanagi Osteonetwork Project

Selective inhibition of NF-κB enhances BMP-induced bone formation

【Speaker】

Eijiro Jimi

Div. of Molecular Signaling and Biochemistry, Kyushu Dental College

Regulatory mechanisms of RANKL subcellular localization as possible therapeutic targets

【Speaker】

Masashi Honma

Dept. Pharm., The Univ. Tokyo Hosp.

S3I32March 24 (Thu) 9：00〜10：30　RoomI（315） Frontier researches on biological imaging toward the development of novel drugs and therapeutics

【Organizers】

Masaru Ishii

Osaka Univ.

Satoshi Nishimura

The Univ. of Tokyo

Chemokine-mediated migration control of bone cells visualized by intravital multiphoton bone imaging

【Speaker】

Masaru Ishii

Lab. Biol. Imaging, Osaka Univ. IFReC

Development of imaging probe specific to hypoxia inducible transcription factor HIF

【Speaker】

Shinae Kondoh

Dept. Biomolecular Engineering

In vivo molecular imaging reveals parenchymal and interstitial cell cross-talks in chronic inflammatory diseases

【Speaker】

Satoshi Nishimura

Dept. of Cardiovasc. Med., The Univ. of Tokyo
PRESTO, Japan Sci. and Technology Agency
TSBMI, The Univ. of Tokyo

S3C33March 24 (Thu) 10：30〜12：00　RoomC（411+412） Development of drugs for brain ischemia: toward translational research

【Organizers】

Masahiro Nishibori

Okayama Univ.

Michihiro Fujiwara

Fukuoka Univ.

Anti-high mobility group box1 monoclonal antibody ameliorates brain infarction

【Speaker】

Hideo Takahashi

Dept. Pharmacol., Okayama Univ. Grad. Sch. Med., Dent. & Pharm. Sci.

Therapeutic potential of non-psychotropic cannabidiol in ischemic stroke

【Speaker】

Kazuhide Hayakawa

Dept. Neuropharmacol., Fukuoka Univ.
MGH-Harvard

Prothymosin α: a novel neuroprotetive polypeptide against ischemic damages

【Speaker】

Hiroshi Ueda

Div. Mol. Pharmacol. & Neurosci., Nagasaki Univ. Grad. Sch. of Biomed. Sci.

Understanding the mechanisms of actions of neuroprotective compounds in animal stroke models

【Speaker】

Kazuya Hokamura

Dept. Pharmacol, Hamamatsu Univ. Sch. Med.

S3I34March 24 (Thu) 10：30〜12：00　RoomI（315） Structural biology and pharmacology: lessons from researches of GPCRs

【Organizers】

Takuya Kobayashi

Kyoto Univ.

Takumi Misaka

The Univ. of Tokyo

The emerging roles of prostaglandin E receptor in immune inflammation

【Speaker】

Daiji Sakata

Dept. of Pharmacol., Faculty of Med., Kyoto Univ.

Characterization of the recognition mechanisms of the bitter taste receptor

【Speaker】

Takumi Misaka

Dept. Appl. Biol. Chem., Univ. Tokyo

Towards structure determination for G protein-coupled receptor

【Speaker】

Takuya Kobayashi

Dept. Cell Biology, Kyoto Univ.
JST ERATO Iwata Human Receptor Crystallography Project

S3C35March 24 (Thu) 14：20〜15：50　RoomC（411+412） The next generation of deafness therapies targeting the inner ear

【Organizers】

Hiroshi Hibino

Niigata Univ.

Katsuhisa Ikeda

Juntendo Univ.

Novel treatment for sensorineural hearing loss using inner ear drug delivery system

【Speaker】

Takayuki Nakagawa

Dept. Otolaryngol., Grad. Sch. Med., Kyoto Univ.

Gene therapy for inner ear diseases

【Speaker】

Sho Kanzaki

Dept. Otorhinolaryngology, Head and Neck Surgery, Keio Univ., Sch. of Med.

Cell therapy for heredity deafness with bone marrow mesenchymal stem cell

【Speaker】

Kazusaku Kamiya

Dept. of Otorhinolaryngol., Juntendo Univ. Sch. Med.

Mechanosensitive hair cell-like cells from embryonic and induced pluripotent stem cells

【Speaker】

Kazuo Oshima

Dept. Otolaryngol., Stanford Univ. Sch. Med.

S3I36March 24 (Thu) 14：20〜15：50　RoomI（315） Visualization of reactive oxygen species and its application to elucidation of signal transduction pathways

【Organizers】

Motohiro Nishida

Kyushu Univ.

Akio Matsumoto

Chiba Univ.

Novel chemical fluorescence sensors for visualization of various ROS in living cells and animals

【Speaker】

Yasuteru Urano

Grad. Sch. of Med., The Univ. of Tokyo

Elucidation of the functions of endogenous nitrated nucleotides using chemical probes

【Speaker】

Hirokazu Arimoto

Tohoku Univ. Grad. Sch. Life Sci.

Importance of H2O2 generation and protein oxidation in Semaphorin3A signaling

【Speaker】

Hiroaki Miki

Inst. Prot. Res., Osaka Univ.

Reactive oxygen species inhibits nitric oxide-mediated signaling pathway for synaptic plasticity

【Speaker】

Sho Kakizawa

Dept. Biol. Chem., Grad. Sch. Pharmaceu. Sci., Kyoto Univ.

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